![]() By that time, umbilical cord blood stem cells will have been shown to be a true 'gift from the gods.'" "Embryonic stem cells have too many limitations, including immune rejection and the potential to form tumors, to ever achieve acceptance in our lifetime. Rosenthal, "The Stem Cell Challenge," Scientific American, June 2004, pp. Creating that many lines could require millions of discarded embryos from IVF clinics." Hundreds of combinations of different types of antigens are possible, meaning that hundreds of thousands of ES cell lines might be needed to establish a bank of cells with immune matches for most potential patients. "ES cells and their derivatives carry the same likelihood of immune rejection as a transplanted organ because, like all cells, they carry the surface proteins, or antigens, by which the immune system recognizes invaders. Rick Weiss, "Stem Cells an Unlikely Therapy for Alzheimer's," Washington Post, June 10, 2004, p. 'Maybe that's unfair, but they need a story line that's relatively simple to understand.'" McKay, a stem cell researcher at the National Institute of Neurological Disorders and Stroke. "'To start with, people need a fairy tale,' said Ronald D.G. "It is a distortion that some admit is not being aggressively corrected by scientists. "iven the lack of any serious suggestion that stem cells themselves have practical potential to treat Alzheimer's, the Reagan-inspired tidal wave of enthusiasm stands as an example of how easily a modest line of scientific inquiry can grow in the public mind to mythological proportions. 'I personally think we're going to get other therapies for Alzheimer's a lot sooner.'. ![]() "'I think the chance of doing repairs to Alzheimer's brains by putting in stem cells is small,' said stem cell researcher Michael Shelanski, co-director of the Taub Institute for Research on Alzheimer's Disease and the Aging Brain at the Columbia University Medical Center in New York, echoing many other experts. "Q & A," Autoimmune Disease Research Foundation, accessed July 2004. Solid data of stable, functioning islet cells from embryonic stems cells in animals has not been seen." The two key challenges to overcome are making the stem cells differentiate into specific viable cells consistently, and controlling against unchecked cell division once transplanted. The field of embryonic stem cells faces enormous hurtles to overcome before these cells can be used in humans. "Is the use of embryonic stem cells close to being used to provide a supply of islet cells for transplantation into humans? 123.įrom a major foundation promoting research in pancreatic islet cells and other avenues for curing juvenile diabetes: ![]() Gesine Kögler et al., "A New Human Somatic Stem Cell from Placental Cord Blood with Intrinsic Pluripotent Differentiation Potential," Journal of Experimental Medicine, Vol. "Although embryonic stem cells have the broadest differentiation potential, their use for cellular therapeutics is excluded for several reasons: the uncontrollable development of teratomas in a syngeneic transplantation model, imprinting-related developmental abnormalities, and ethical issues." Foley "Stem cell pioneer warns of roadblocks before cures," San Jose Mercury News Online, posted on Feb. ![]() 'Ultimately, those transplation therapies should work but it's likely to take a long time.'.Thomson cautioned such breakthroughs are likely decades away." 'I don't want to sound too pessimistic because this is all doable, but it's going to be very hard,' Thomson told the Wisconsin Newspaper Association's annual convention at the Kalahari Resort in this Wisconsin Dells town. University of Wisconsin scientist James Thomson said obstacles include learning how to grow the cells into all types of organs and tissue and then making sure cancer and other defects are not introduced during the transplantation. "Major roadblocks remain before human embryonic stem cells could be transplanted into humans to cure diseases or replace injured body parts, a research pioneer said Thursday night. Use of stem cells obtained by destroying human embryos is not only unethical but presents many practical obstacles as well. While some researchers still claim that embryonic stem cells (ESCs) offer the best hope for treating many debilitating diseases, there is now a great deal of evidence contrary to that theory. ![]()
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